Supercritical Carbon Dioxide-Assisted Nebulization To Produce Fine Particles Of Stable Protein Formulations
Robert E. Sievers - American Association of Pharmaceutical Sciences Meeting, Arlington, Virginia, April, 2002
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Some factors that determine particle size

  • Concentration
    Decrease in concentration decreases particle size
     
  • Diameter of flow restrictor (40 to 175 microns, no significant change in size)
     
  • Drying temperature
     
  • Viscosity and surface tension of soln.
     
  • Morphology: Solid vs. hollow particles
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