Supercritical Carbon Dioxide-Assisted Nebulization To Produce Fine Particles Of Stable Protein Formulations
Robert E. Sievers - American Association of Pharmaceutical Sciences Meeting, Arlington, Virginia, April, 2002
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Conclusions

  • A new nebulization method (CAN-BD) has been presented that can generate fine pharmaceutical particles (1-3 µm) suitable for use in a dry powder inhaler (DPI) or metered dose inhaler (MDI).
     
  • Drying requires only seconds and no organic solvents are needed.
     
  • The method is based on mixing CO2 and an aqueous or organic solution at room temperature and 100 bar, and then expansion of the microemulsion into a drying chamber at 0 to 70°C and below or near atmospheric pressure.
     
  • Retention of enzymatic activity results when certain stabilizing sugars and surfactants are present.
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