Supercritical Carbon Dioxide-Assisted Nebulization To Produce Fine Particles Of Stable Protein Formulations
Robert E. Sievers - American Association of Pharmaceutical Sciences Meeting, Arlington, Virginia, April, 2002
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Conclusions, cont.

  • Since the entire nebulization and drying method is carried out at lower temperatures than in other conventional spray drying processes, it is applicable to many temperature-sensitive pharmaceuticals, vaccines, Mab and proteins.
     
  • Particle formation is in thin walled drying chambers near atmospheric pressure; no high pressure autoclaves are required.
     
  • The usually preferred process is continuous rather than batch; the Colorado patents claim both methods.
     
  • For room temperature stable powders, dry at temperatures near room temperature.
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