Supercritical Carbon Dioxide-Assisted Nebulization To Produce Fine Particles Of Stable Protein Formulations
Robert E. Sievers - American Association of Pharmaceutical Sciences Meeting, Arlington, Virginia, April, 2002
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ROOM-TEMPERATURE-STABLE ANTIBODIES, ANTIBIOTICS, AND VACCINES

Strategy:  Dry powders near room temperature for alveolar or nasal administration (or rapid redissolution)

Studies:

“Stabilization and Dehydration of Monoclonal Antibodies”
- Avoid aggregation and create rapidly redissolved microparticles
 
“Preparation of Stable Dry Powder Formulations of Live Attenuated Virus Vaccines for Nasal Delivery”
- Use Bubble Dryer® to process dry powders of vaccine formulations that are easier to ship, store and maintain activity.
 
“Inhalable Antibiotics”
- Micronize dry powder antibiotics for delivery to alveoli
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