Supercritical Carbon Dioxide-Assisted Nebulization To Produce Fine Particles Of Stable Protein Formulations
Robert E. Sievers - American Association of Pharmaceutical Sciences Meeting, Arlington, Virginia, April, 2002
 1  2  3  4  5  6  7  8  9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32
next page

Primatized Anti-CD4 Antibody

  • Size distribution (by Aerosizer) and SEM of primatized monoclonal antibody micronized by CAN-BD from a buffered solution containing saccharide and surfactant. Dried at 50°C.
     
  • Mean diameter = 1.4 µm; with 95% under 3.5 µm
     
  • 3.5% H2O (within a day of micronization)
    2.0% H    2O (after 6 days storage in vacuum desiccator)

Stephen P. Cape, Ph.D.
next page