Lecture presented on April 28, 2003, at the Intl. Soc. for Applications of Supercritical Fluids Meeting in Versailles, France.
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Alpha-1-Antitrypsin
  • Size distribution (by Aerosizer) and SEM of alpha-1-antitrypsin micronized by CAN-BD from an aqueous solution (2.8% AAT, 4.6% trehalose in 0.1M sodium phosphate, 0.1% Tween 20, pH 7.0). Dried at 40 °C.
  • Mean diameter = 2.2 µm; with 95% under 5.3 µm
  • Moisture content = 7.5% H2O (initial), 1.8% H2O (after storage in vacuum desiccator)
  • Activity retained after processing = 98% ± 2%
  • Completely redissolves in a few minutes with gentle swirling

Stephen P. Cape, Ph.D.
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