Lecture presented on April 28, 2003, at the Intl. Soc. for Applications of Supercritical Fluids Meeting in Versailles, France.
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ROOM-TEMPERATURE-STABLE ENZYMES, ANTIBODIES, AND PHARMACEUTICALS

Strategy: Stabilize and dry powders near room temperature by SF processing

  • Nanoparticle and Microparticle Synthesis and Coating
     
  • Inhalable Antibiotics
     
  • Inhalable Antielastase Protein Enzyme for Emphysema and Cystic Fibrosis
     - Micronize dry powder alpha-1-antitrypsin for delivery into alveoli
     
  • Stabilization and Dehydration of Monoclonal Antibodies
     - Stabilize with sugars; dry and store without freezing or refigeration
     - Avoid aggregation and create rapidly redissolved microparticles
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