Conclusions

• A nebulization, and drying and coating method (CAN-BD) has been presented that can manufacture dry powders of proteins, enzymes, antibodies,and other drugs without detectable degradation.
   
• Both solutions and suspensions can be processed.
   
• Coating and drying requires only seconds at near- ambient conditions of temperature and pressure.
   
• Water and many organic solvents yield nanoparticles and microparticles.
   
• Fluid ratios and solute concentrations determine size.
   
• Multiple constituents can be incorporated in three fluids in a low volume cross to make heterogenous and homogenous nanoparticles and microparticles.